Chemical Etiology of Nucleic Acid Structure
نویسندگان
چکیده
منابع مشابه
Chemical etiology of nucleic acid structure.
Systematic chemical studies indicate that the capability of Watson-Crick base-pairing is widespread among potentially natural nucleic acid alternatives taken from RNA's close structural neighborhood. A comparison of RNA and such alternatives with regard to chemical properties that are fundamental to the biological function of RNA provides chemical facts that may contain clues to RNA's origin.
متن کاملNucleic Acid Templated Reactions for Chemical Biology
Nucleic acid directed bioorthogonal reactions offer the fascinating opportunity to unveil and redirect a plethora of intracellular mechanisms. Nano- to picomolar amounts of specific RNA molecules serve as templates and catalyze the selective formation of molecules that 1) exert biological effects, or 2) provide measurable signals for RNA detection. Turnover of reactants on the template is a val...
متن کاملThe Structure of Yeast Nucleic Acid
The tetranucleotide theory of the structure of yeast nucleic acid was first enunciated by the writer1 and was subsequently conclusively demonstrated by the experimental evidence furnished by Levene and Jacobs,2 ‘and by Levene and La Forge.3 The facts on which the theory was based were: first, the isolation of four nucleosides; second, the isolation of simple pyrimidine nucleotides. These were o...
متن کاملThe Structure of Yeast Nucleic Acid
Levene and Jacobs have formulated the structure of yeast nucleic acid as a tetranucleotide. The facts that led up to their formulation were: 1. The formation of four nucleosides on neutral or ammonia hydrolysis. 2. The formation of simpler nucleotides on hydrolysis with dilute mineral acids. 3. The presence of a phosphorus to nitrogen ratio which agreed quite well for t.he tetranucleotide theor...
متن کاملDuplex Structure of a Minimal Nucleic Acid
The crystal structure of an 8-mer (S)-GNA duplex is presented. As a tool for phasing, the anomalous diffraction of two copper(II) ions within two artificial metallo-base pairs was employed. The duplex structure confirms a canonical Watson-Crick base pairing scheme of GNA with antiparallel strands. The duplex secondary structure is distinct from canonical A- and B-form nucleic acids and can be d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 1999
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.284.5423.2118